منابع مشابه
Cloning of Minor Autolysin of Streptococcus Pneumoniae
Abstract Background and Objective: Increased antibiotic resistant strains and inadequacy of current vaccines against pneumococcal infections necessitate the study of novel protein antigens. It seems that minor autolysin of Streptococcus pneumoniae may have antigenicity. Thus, we aimed at cloning its gene for the first time. Material and Methods: After DNA extraction of Streptococcus pneumoniae ...
متن کاملDrug-resistant Streptococcus pneumoniae.
Streptococcus pneumoniae remains a major cause of infection in both children and adults, annually resulting in significant morbidity and mortality. The past two decades have seen an alarming worldwide increase in the incidence of drug-resistant S. pneumoniae (DRSP). DRSP is now common throughout the United States, and physicians are questioning how best to approach this epidemic. With the intro...
متن کاملPenicillin-resistant Streptococcus Pneumoniae
Streptococcus pneumoniae is a major cause of pneumonia, meningitis, septicemia, acute otitis media, and other serious infections, severely affecting infants, young children, and the elderly. In the past, S. pneumoniae was uniformly susceptible to penicillin, which remained the drug of choice for serious infections. However, since the mid-1960s, resistance to penicillin, which was first reported...
متن کاملTelithromycin-resistant Streptococcus pneumoniae
To the Editor: In recent years, antimicrobial drug resistance in Streptococcus pneumoniae has increased worldwide and is a major health concern. Resistance to β-lac-tams and macrolides, considered to be first-line therapeutic agents, is particularly high in France and many Asian countries (1–3). Resistance to new fluoroquinolones is reported with increasing frequency, which emphasizes the need ...
متن کاملFluoroquinolone-resistant Streptococcus pneumoniae
To the Editor: In pneumococci, resistance to fluoroquinolones is associated with chromosomal mutations in the quinolone-resistance–determining regions (QRDR) of type II topoiso-merase enzymes, predominantly gyrA and parC. Several mutations have been described in these enzymes, but only a few have been shown by in vitro studies to confer resistance: S81F or Y, C, or I and E85K in gyrA; E474K in ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2015
ISSN: 0021-9258
DOI: 10.1074/jbc.m115.673632